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This disparity led to the accumulation of hydrogen peroxide (H 2 O 2 ), as evidenced by heightened lipid peroxidation and diminished mitochondrial complex-I activity, ultimately inducing apoptosis
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Additionally, ROS can promote endothelial fibrosis, resulting in downregulation of adhesion proteins, thereby compromising endothelial integrity and increasing permeability (48)
doi:10.2337/dc10-0452
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