fda compounding semaglutide crackdown news today 2025 restricts non-approved compounded GLP-1 weight loss products Hims & Hers stock falls

External eating is the tendency to eat in response to external cues, such as sights, smells, or the availability of food, rather than to internal feelings of hunger or fullness

Some practitioners are using them sequentially, starting with semaglutide and switching to tirzepatide if response is suboptimal, similar to how switching between GLP-1 agents works in metabolic contexts

For diabetes patients, A1c reductions of approximately 1.0-1.5 percentage points are common with GLP-1 receptor agonists, while tirzepatide has shown reductions of up to 2.0-2.3 percentage points in clinical trials

The authors concluded that obesity behaves like a chronic condition, and that ongoing treatment is generally needed to maintain the improvements in weight and health

Final Thoughts Sublingual semaglutide is more than just an alternative to injections it represents a significant opportunity to improve access, adherence and possibly unlock new therapeutic applications