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Entre los efectos no dependientes del peso, se ha postulado el efecto directo o indirecto de los arGLP-1 sobre los vasos sanguneos, modulando la funcin endotelial, la estabilidad de la placa o la vasodilatacin, y sobre el miocardio, donde podran mejorar la contractilidad cardaca, la tolerancia a la isquemia o la captacin de glucosa, as como reducir la fibrosis cardaca, entre otros (fig