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Altogether, these reports demonstrate, not only the presence of MCRs in multiple types of fibroblasts, but their active involvement in the endogenous control of their functions, suggesting MCRs, and particularly MC 1 , as plausible therapeutic targets for the treatment of fibroblast-mediated conditions

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Understanding the evidence, safety considerations, and lack of proven synergistic benefit is essential for informed clinical decision-making when patients consider combining these treatments

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