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Induction of apoptosis in AML by HA14-1, A cell-permeable organic compound identified by protein structure-based computer screening that binds the BH1 to BH3 surface pocket of Bcl-2

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The TRIUMPH-4 trial enrolled participants with BMI of 35 or higher, and the average weight loss of 71 pounds demonstrates the compound ability to make transformative changes in severe obesity

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