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Another review of 23 randomized controlled trials found that creatine supplementation improved memory scores in otherwise healthy people, especially adults ages 66 to 76 years

However, after intranasal application, it stimulates memory and attention in rodents and humans

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Specifically, for Ser31 and Gly35, which form a common small-X3-small motif frequently observed in transmembrane helix pairs (PMID: 26725515), the mutation range was restricted to small amino acids (ASGT)