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It has been shown to inhibit the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway, leading to a reduction in pro-inflammatory cytokines such as TNF- and IL-6 in liver tissues

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Used in explaining increased frequency of seizures in epilepsy and progression of bipolar disorder in humans. Jason et al have recently (2011) proposed kindling as an etiological model for ME/CFS : Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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