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Many tyrosinase inhibitors, such as hydroquinone 23,24,25,26 , kojic acid 20 , azelaic acid 27,28 , electron-rich phenols 29 and arbutin have been tested in pharmaceuticals and cosmetics for their capability of preventing overproduction of melanin 30,31

The FDA label carries a warning based on post-marketing reports, though the STEP trials did not show a statistically significant increase in confirmed pancreatitis cases 24

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This engagement extends beyond sexual signaling and interacts with broader appetite and reward biology pathways

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