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Dual agonist (Tirzepatide): Mentioned earlier, tirzepatide (Lilly) is a single peptide that activates both the GLP-1 and GIP (Glucose-dependent Insulinotropic Polypeptide) receptors

Additionally, Zealand pharma (ZEAL DK) and Altimmune (ALT NASDAQ) are both developing dual agonists targeting GLP-1 and Glucagon receptors

Integration of GLP-1RAs with Guideline-directed Medical Therapy and the Management of Other Comorbidities A key practical question is how to integrate GLP-1RAs with existing therapies for HFpEF and its common comorbidities

Retatrutide builds upon this concept by targeting GLP-1, GIP, and glucagon receptors simultaneously

KDIGO=Kidney Disease: Improving Global Outcomes