The conversion from cyanocobalamin to active forms requires several enzymatic steps and adequate amounts of other nutrients including folate, riboflavin, and various minerals
Oh, I am also in the process of moving about 600 miles away
In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
We recently reported that NNMTi treatment combined with a low-fat, or lean, diet (LD) returned systemic adiposity and liver pathologies of obese animals to the adiposity and liver pathology levels of LD controls
This is analogous to injecting a dense concentration of methyl-B12 into the subcutaneous fat in a childs buttocks a process of slow steady release over 3 days