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Reduced Depressive Symptoms This 2024 review found evidence that GLP-1 medications may help reduce symptoms of depression

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Enteral Routes (Via Gastrointestinal Tract) Oral (PO) Most common and convenient route Drug absorbed mainly in the small intestine Subject to first-pass metabolism (liver) Clinical Insight: Suitable for chronic therapy but not ideal in vomiting/unconscious patients Sublingual / Buccal Absorption through oral mucosa Bypasses first-pass metabolism Rapid onset Example: Nitroglycerin in angina Rectal Used when oral route is not feasible Partial avoidance of first-pass metabolism Limitation: Erratic absorption 2

Believed to have higher bioavailability, meaning it may be absorbed more efficiently by the body

Prominent features include epithelial barrier dysfunction, delayed or accelerated gastrointestinal transit due to abnormal function of smooth muscles, dysfunctional enteric nervous system and/or immunity, gut microbial dysbiosis, bile acid malabsorption, and alterations in the gut-brain axis (812)