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While the greater amount of cellular reduced GSH is found in the cytosol and mitochondria, the endoplasmic reticulum becomes a reservoir of small concentrations of the oxidized form of GSH (GSSG)

Health and lifestyle information included smoking status (non-smoker vs current smoker), alcohol consumption as units per week, physical activity assessed using the International Physical Activity Questionnaire (IPAQ, expressed in Metabolic Equivalent Total (MET) minutes per week [46], and body mass index (BMI) measured during physical examination

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The National Institute for Health and Care Excellence (NICE) guideline NG28 recognises both drug classes as treatment options within the type 2 diabetes management pathway

Many people on these medications report changes in their digestive system, including difficulty with bowel movements