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When we do our job, not only landscapes are changed, but lives are transformed as well

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Under hypoxic or ER stress conditions, ATF4 upregulates BH3-only proteins such as HRK, PUMA , and NOXA , which influence mitochondrial integrity and autophagy

We employed conventional statistical methods, survival analysis, multivariable regression, machine learning feature importance, and unsupervised K-means clustering to identify distinct patient phenotypes