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Although ergothioneine is present in plants and animals, evidence for ergothioneine biosynthesis, to date, is limited to bacteria and fungi (9,10)

The acidic gastric environment (pH 1-2), together with proteolytic enzymes such as pepsin, trypsin, and chymotrypsin, promote extensive degradation and shorten residence times (New, 2021

In a clinical trial, the GLP-1 analogue liraglutide added to metformin significantly lowered HbA1c in comparison with metformin alone 47

Clinically, GLP-1 RAs were initially approved for type 2 diabetes mellitus (T2DM) management, demonstrating durable glycemic control and cardiovascular risk reduction in trials ( [3] )