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This study aims to investigate whether semaglutide can reduce the progression of noncalcified coronary atherosclerotic plaque volume, as measured by serial coronary computed tomography angiography (CTA), over a one-year period compared to a placebo, in individuals with diabetes

Chronic semaglutide treatment promotes changes in substrate oxidation Consistent with the composition of the 60% HFD and feeding patterns, the respiratory exchange ratio (RER) in vehicle-treated mice vacillated steadily between 0.75 and 0.8, indicative of greater lipid oxidation relative to carbohydrate oxidation ( Figure 4A-B )

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