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Class IIa HDACs can shuttle between the nucleus and cytoplasm following diverse cell signal stress while the distributions of class IIb HDACs are mainly detected in the cytoplasm [57]

The CBB-stained gel was digitally imaged (GelDoc, Bio-Rad, USA) under UV excitation, and the image was analyzed with the software PDQuest 2D Elite

During this phase, managing inflammation becomes important because excessive inflammatory signaling can disrupt the delicate process of stem cell differentiation

Injections may also cause reactions at the injection site, such as redness or irritation

As such, this phenomenon is involved in the etiopathogenesis of numerous diseases, such as atherosclerosis, reduced kidney function, or ischemic stroke [26,27,28]