84 , 161 (Figure 3) For example, histones from NETs directly activate the NLRP3 inflammasome by disrupting lysosomal membranes and releasing cathepsins into the cytosol, which in turn activates the NLRP3 inflammasome that assembles with ASC and pro-caspase-1 followed by the step to cleave the pro-caspase-1 into caspase-1 and finally the release of IL-1 (Figure 3)
Thomsen et al., 2019
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Additinally, I didnt plan to watch a video learning about the incredible array of benefits from GHK-Cu, but the YT vid you posted with Dr Quinn Stillson, breaking down the physiology, current levels of research, efficacy, risks and benefits of topical vs sub -cu, was simply phenomenal
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