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all participants who received at least one dose of the study medication (semaglutide or metformin) and had at least one post-baseline assessment, were included in the efficacy analyses

On the latter, studies conducted using site-specific brain micro-injections and single-photon emission computed tomography documented a novel regulatory role of the hypothalamic supramammillary nucleus in the regulation of food intake and reward, posing this brain area as one of the main targets of the GLP1/E conjugate, along with the lateral hypothalamus and the nucleus of the solitary tract, whose activation may be responsible for the anorectic, weight-lowering and reward reducing effects of this multi-agonist 51

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Another study of GLP-1 use, for over 20 weeks, showed approximately 10% (11 kg or 23 lbs) weight loss