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Beyond 8 weeks: The healthcare provider may adjust the dose based on response and goals, potentially up to 15 mg weekly

Zhou ZD, Yi L, Popawska-Domaszewicz K, Chaudhuri KR, Jankovic J, Tan EK (2025) Glucagon-like peptide-1 receptor agonists in neurodegenerative diseases: Promises and challenges

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In the STEP-1 study published by The New England Journal of Medicine , people who combined a 2.4 mg dose of semaglutide with healthy lifestyle habits lost, on average, about 15% of their body weight