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(1993): Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration

Since then, newer agents have been developed with enhanced pharmacokinetic properties while considering safety issues

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Sitagliptin at therapeutic concentrations does not inhibit the activity of related enzymes DPP-8 or DPP-9

While it is well-established that intestinal GLP-1 cells can exert influence through paracrine mechanisms, recent evidence suggests the possible existence of synaptic-like connections between GLP-1 cells and peripheral neurons, including those of the vagus nerve