According to a study of 23 patients with drug-resistant Alzheimers disease, acetyl-carnitine may boost the effectiveness of standard drugs, such as donepezil (Aricept) and rivastigmine (Exelon) [41]
This interaction activates -secretase-mediated proteolytic cleavage of the Notch intracellular domain, which ultimately targets Hes1 and inhibits MUC5AC transcription
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