Further trials should conduct better randomization and blinding procedures, recruit more participants, and provide adequate reporting
Studies examining safety and tolerability in rodents have generally not reported concerning toxicity signals at doses producing metabolic benefits, though comprehensive toxicology studies and long-term safety data are limited
The animals were anesthetized by inhalation route with Isofluorane (Isboa Vet) using a vaporizer and intranasal administration was performed with two instillations of 20 l of the bacterial suspension prepared in PBS
The presentation is documented for catalog supply and standardized bench routines
In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]