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Abbreviations AACE American Association of Clinical Endocrinology AE Adverse event CDS Chinese Diabetes Society DPP-4i Dipeptidyl peptidase-4 inhibitor ETD Estimated treatment difference FPG Fasting plasma glucose GLP-1 Glucagon-like peptide-1 GLP-1RA Glucagon-like peptide-1 receptor agonist PIONEER Peptide Innovation for Early Diabetes Treatment SAE Serious adverse event SF-36v2 36-item Short Form Health Survey (Acute Version) SMPG Self-monitored plasma glucose Acknowledgements Medical writing and editorial support were provided by A

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