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Furthermore it was illustrated that multiple lysosomotropic compounds can redistribute the mannose 6-phosphate receptor from the trans-Golgi network to endosomes and concomitantly increase the secretion of lysosomal enzymes, resulting in a decline of intracellular lysosomal enzyme levels [36], which could further exacerbate the lysosomal dysfunction

Geranylgeranylacetone ameliorates beta-amyloid toxicity and extends lifespan via the heat shock response in Caenorhabditis elegans

10.1016/j.eats.2016.02.037 182 OllivierB.BergerP.DepuydtC.VandenneuckerH