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The qualifying comorbidities most commonly recognized in clinical practice include type 2 diabetes, hypertension, obstructive sleep apnea, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), and established cardiovascular disease

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T2DM appears to have common pathophysiological mechanisms with the development of cognitive disorders such as Alzheimers and Parkinsons diseases (AD and PD) associated with insulin resistance