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The RNA sequencing data lead us to find that ATF4-mediated gene transcription network 21,22,23 is more active in T315I-Bcr-Abl cells

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Cancer 1870 , 3242 (2018)

It is important to note that ITCs exhibit a hormetic dose-response: low dietary doses may have negligible or even protective effects on cells, whereas higher pharmacological doses are required for cytotoxic antitumor activity (113)