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In vivo, it is secreted by the L-cells of the small intestine in response to nutrient ingestion

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Deubiquitination of active NLRP3 triggers ASC aggregation and the recruitment of precaspase-1, which leads to the formation of the NLRP3 inflammasome and the release of proinflammatory cytokines such as IL-1 and IL-18

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In Korea, duloxetine is currently available, but venlafaxine is not