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Yaikwawong and colleagues (Yaikwawong et al., 2025) reported in a 12-month randomized controlled trial in 78 patients with T2D and MASLD that 1,500 mg/day curcumin significantly reduced TNF-, IL-1, IL-6, and malondialdehyde levels at all follow-up intervals (3, 6, 9, and 12 months) while increasing antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase) and significantly improving hepatic steatosis and liver stiffness measured by FibroScan

Washida, K., Hattori, Y

All treatments were carried out in starved 2:1 melanocyte media for the duration of experiments

For example, a 2021 review discussed possible ways NAC could help counter ROS-related survival, metastasis, and drug-resistance pathways in triple-negative breast cancer.39 And in a small uncontrolled pilot study involving women with breast cancer, NAC supplementation was associated with reduced markers of tumor cell proliferation.40 But animal research has found concerning effects in other contexts