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(2012) Lipid effects of peroxisome proliferator-activated receptor- agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome

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The absence of documented adverse events reflects the absence of studies, not proven safety

In addition, the ZFPG + US treatment down-regulated the expression of the fatty acid synthase ( FASN ) gene, which could enhance the occurrence of ferroptosis by altering lipid metabolism and increasing lipid peroxidation (Figs

Weight loss was associated with a lower likelihood of stopping treatment, while gastrointestinal adverse events increased discontinuation risk