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Such claims lack human trial support

This was because in contrast to mammals where the islets of Langerhans are embedded in the exocrine pancreas, in fish, the islets reside in a separate organ known as Brockman bodies, thus providing an enriched source of glucagon-producing cells

Vigorous shaking or swirling

Zeisel SH, Mar MH, Howe JC, Holden JM

The overall impression from available evidence is that DSIP appears reasonably well-tolerated with a low incidence of serious adverse effects in the populations and contexts studied, but significant gaps in safety knowledge remain, particularly regarding long-term use, use in specific populations (elderly, children, those with comorbidities), and comprehensive toxicology assessment meeting modern pharmaceutical standards