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These salt forms of GLP-1s have not been proven safe and effective in humans or approved by the FDA, Basina noted, adding that effectiveness can be different due to the salt form differences. Additives To differentiate their products from the FDA-approved GLP-1s, many compounders add extra ingredients most commonly vitamin B12, but also B6, niacinamide, glycine or carnitine that have no proven benefit for weight loss or diabetes management

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GLP-1 slows gastric emptying, reduces appetite, and promotes a feeling of fullness after meals

PlexusDx compounded semaglutide injections (at $189/mo month-to-month, or from $149/mo on the 6-month plan) are prescribed for weight management and metabolic health

However, the high cost of GLP-1 receptor agonists and limited access to these therapies in certain regions may act as restraining factors