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Rutin specifically downregulated phosphorylated JNK1/2, while quercetin demonstrated a more substantial inhibitory effect on multiple mitogen-activated protein kinase (MAPK) pathway proteins, including extracellular signal-regulated kinases (ERKs) and p38 (Siti et al., 2021b)

Historical parallels suggest the pharmaceutical industry may pursue formal approval and reposition GLP-1 drugs for these emerging conditions

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