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Palliyaguru DL, et al

Individual response varies widely based on genetic factors, metabolic markers, and clinical history

2 Pathophysiology In T1DM and advanced T2DM, glucose counterregulation is compromised by the impaired secretion of insulin, glucagon, and epinephrine, breaching three physiological defenses against hypoglycemia

The intracellular signaling cascades activated during dosing PI3K/Akt/mTOR for synthesis, FoxO suppression for anti-catabolism do not terminate immediately when plasma LR3 clears (Yoshida & Delafontaine, 2020)