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For probiotics, the transient nature of colonization means that effects often disappear after cessation of supplementation, limiting their long-term therapeutic value

Have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food

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Due to their preclinical testing and lack of comparison with other dual receptor agonists such as tirzepatide, further studies are needed to determine whether the effects of these unimolecular compounds are superior to those of clinically tested drugs