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Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire

This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome

Reference: PubMed (2022)

Tirzepatide and additional dual GLP-1/GIP receptor agonists that could eventually be developed in the future seem to be a promising furthest advance for the management of several cardiometabolic settings

Lackner, C