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Several enzymes involved in the glutathione pathway, such as -glutamylcysteine synthetase (GCLC), glutathione synthetase (GSS), glutathione peroxidase 4 (GPX4), and glutathione reductase (GSR), are regulated, at least in part, by Nrf2 through its activation of the Nrf2-antioxidant response element

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This copper-peptide bond produces the compound's biological effects, triggering gene expression changes that promote anti-aging and tissue repair responses

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For individuals with low blood pressure, the question of safety arises when considering glutathione supplementation