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The observed differences in free GSH, GSSG, and their respective ratio is likely due to spontaneous oxidation of free GSH in the heparinized plasma rather than a matrix effect of anticoagulant type used during sample collection

Kretschmar M, Klinger W (1990)

However, there is some evidence that it might benefit people exposed to brief periods of severe physical exercise (marathon runners) or cold environments (skiers and soldiers in subarctic conditions)

The effect is a reduced appetite and cravings

The compounding industry pushed back, with a trade group filing a lawsuit against the FDA, arguing that the drug was actually still hard to access for patients