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In monotherapy adult clinical trials of topiramate 50 to 200 mg per day for migraine prophylaxis, the following effects occurred more frequently in the active treatment groups than the placebo group: memory impairment (7% to 11% vs
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Similarly, the SURMOUNT trials evaluating tirzepatide for weight management did not report increased rates of panic symptoms compared to placebo, though it's important to note that panic symptoms were not prespecified outcomes in these studies
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