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Non-alcoholic fatty liver disease as an emerging risk factor for heart failure

Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

On this background, a synthetic replica of exendin-4, exenatide, was developed for clinical T2DM therapy with two daily injections (110)

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In the adipose tissue of insulin-resistant and obese patients, treatment with selenite was shown to enhance insulin receptor expression in 3T3-L1 pre-adipocytes, improving adipocyte differentiation and function through the induction of GPX3 expression and activation of the transcription factor SP1 [26]