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This research theorized that hyperglycemia can lead to a downregulation of GIPr causing decreased GIP response despite therapeutic or even supratherapeutic levels of GIP [21]

This natural hormone begins working within minutes to help regulate appetite and blood sugar by: Signaling your brain that youre becoming full Slowing the rate at which food leaves your stomach Stimulating insulin release when blood sugar rises Reducing glucagon, a hormone that raises blood sugar The catch

doi:10.1016/j.jalz.2013.12.005 272

Exendin-4 attenuates brain mitochondrial toxicity through PI3K/Akt-dependent pathway in amyloid beta (1-42)-induced cognitive deficit rats