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As depicted in Figure 4, unscavenged superoxide inactivates aconitase by displacing Fe +2 from the Fe-S cluster, which then promotes the formation of the damaging hydroxyl radical via reaction with H 2 O 2 and Fenton chemistry

doi: 10.1210/jc.2018-00509 111 ValkoMRhodesCJMoncolJIzakovicMMazurM

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[i] Early Phase 1 clinical trials provide data on the safety of drug candidates in humans, as well as indications regarding their mechanism of action