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Quercetin protects against MPP + /MPTP-induced dopaminergic neuron death in parkinsons disease by inhibiting ferroptosis

These adaptations evolved to protect against starvation but work against modern weight loss efforts

Perhaps not surprising, this hindbrain site of action is also responsible for mediating the illness-like behaviors (e.g., nausea, conditioned taste avoidance, emesis) of systemically delivered GLP-1R agonists (43)