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Similar content being viewed by others Introduction The liver is a vital organ that governs over hundreds of physiological processes, including nutrient metabolism 1 , detoxification 2 , bile secretion 3 , and protein synthesis 1 , serving as the bodys primary metabolic hub 4,5

Indeed, drug resistance is also related to increase discharge (efflux) of anticancer drugs due to the overexpression of the efflux transporters

Subsequently, a small-animal ultrasound system (Vevo F2, Canada) equipped with a linear 46-MHz probe was utilized to obtain long-axis M-mode aortic images and to assess aortic blood flow velocity using Doppler mode