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Due to the uncertainty regarding the optimum balance of GLP-1R and GCGR agonism in a unimolecular co-agonist, development of novel peptides varied from sequence modification and enhancing stability of native OXM, sequence modification of the glucagon peptide to confer increased GLP-1R potency or modification of GLP-1 peptide to confer increased GCGR potency

Some evidence suggests combining the two approaches may be superior to either alone

Hedberg-Oldfors C, Eliasdottir O, Geijer M, Lindberg C, Oldfors A (2022) Dominantly inherited myosin IIa myopathy caused by aberrant splicing of MYH2

and Yu L

Lifestyle Factors Beyond Supplements While ashwagandha is a popular tool, it is just one part of the puzzle