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Probably, the peptides can exhibit different specificities against microorganisms, as observed in mice [151], or the expression level of the -defensin genes along the intestinal tract shows large variations to optimize the local regulation of bacterial colonization [153]

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For example, the multiple target optimal intervention (MTOI) method can identify potential drug targets and suggest optimal target intervention combinations

reported mitochondrial EPAC1 mediated MPTP opening via VDAC1/GRP75/IP3R1 complex, thereby triggering myocardial cell death 131

Kampa M, Pelekanou V, Gallo D, et al