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Dbska-lizie A, Kawecka A, Wojnarowski K, et al

Reaction velocities or transport velocities begin with a capital V followed by the name of the enzyme, the transporter, or the process as a subscript

This dual role underpins the concept of biased agonism, where different ligands selectively favor either G-protein-mediated or -arrestin-mediated signaling, allowing for fine control over therapeutic outcomes and side-effect profiles

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Overall, tolerability appears consistent with other incretin-based therapies, though the triple agonist mechanism introduces a broader physiological effect profile