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The researchers then looked at whether women were diagnosed with a new breast cancer in two different cohorts: the full group of 111,646 women and a smaller cohort of 30,528 women, including one-to-one controls for each of the 15,264 GLP-1 cases, matched across age, race, ethnicity, BMI, breast density, and diabetes status to limit bias and potential confounding

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This paradoxical vulnerability indicates that GSH-dependent redox homeostasis, while essential for normal cellular function, can become a critical liability in cancer cells with dysregulated GSH metabolism