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Acknowledgements This work was supported by the National Key Research and Development Program of China (2021YFF1000601), the National Natural Science Foundation of China (32172700) and the Joint Funds of the National Natural Science Foundation of China (U20A2052), and the Fundamental Research Funds for the Central Universities (grant number 2662018PY043)

Ethics statement The animal study was reviewed and approved the Ethics Committee of School of Medicine Zagreb

Creatine is an organic compound produced in the body from three amino acids (methionine, glycine, and arginine) found in certain foods like red meat, poultry, and fish

Semaglutide works by regulating appetite and supporting healthy, sustainable weight loss

Nature 347 , 151156 (1990)