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22 and in 9.8% of subjects receiving 1.8 mg/day (LEAD-5)

These benefits have been demonstrated in large, well-designed cardiovascular outcome trials, including: Liraglutide (Victoza) the LEADER trial , which showed a significant reduction in cardiovascular death and all-cause mortality Semaglutide (Ozempic) the SUSTAIN-6 trial , demonstrating fewer major adverse cardiovascular events, particularly stroke Dulaglutide (Trulicity) the REWIND trial , which showed a significant reduction in major cardiovascular events even in people without established cardiovascular disease Tirzepatide (Mounjaro) cardiovascular outcome data from the SURPASS-CVOT programme are emerging, with early results suggesting cardiovascular benefit compared with insulin therapy These cardiovascular effects are a key reason why GLP-1based therapies are now recommended earlier in the treatment pathway for people with type 2 diabetes who have established heart disease or are at high cardiovascular risk

Discover ingredient solutions for sugar reduction, fiber enrichment and plant-based proteins to meet GLP-1-driven consumer demands

The side effects of these drugs are not fully known, particularly longer-term ones, another reason payers may delay their decision-making process as regards to the current weight-loss drugs, Rayburg said

Understanding GLP-1 Medication and Its Uses GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone in our bodies that plays a crucial role in regulating blood sugar levels and influencing appetite