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In a 68-week clinical trial, patients treated with GLP-1 experienced an average weight loss of 14.9% from their initial body Trusted Source Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial Rubino D, Abrahamsson N, Davies M, et al Go to Source weight

Common temporary side effects include: Mild redness Slight swelling Bruising Tenderness Minor itching These usually settle within a few days

Sleep disturbances Some people using semaglutide report experiencing sleep disturbances or insomnia

Participants in trials have experienced an average weight loss of up to 24% of their body weight over the course of the study

Deficiencies can lead to skin conditions, hair loss, or brittle nails